Understanding the determinants of historical trends in greenhouse gas (GHG) emissions is crucial for countries to formulate effective climate change mitigation strategies and decouple future economic growth from emissions. This study employs input-output structural decomposition analysis to examine the drivers of Argentinian GHG emissions from 2000 to 2016. Our findings reveal that the most influential factor affecting GHG emissions variation is the final demand, exhibiting an increase during economic growth and stagnation periods and a reduction during recessions. Concurrently, the energy intensity effect plays a pivotal role, comparable to that of final demand but exhibiting an inverse impact on emissions changes during economic downturns and growth phases. The alteration in the intermediate consumption structure marginally impacts periods of growth and stagnation, while it has a moderate effect during recessions. The emission intensity effect contributes to emissions growth during periods of growth acceleration and contributes to emissions reduction during growth and stagnation. The outcomes underscore that, in conjunction with the energy intensity effect, the level of final demand is the primary driver of GHG emission variations in most years. The study provides robust evidence supporting the promotion of enhanced energy efficiency as a highly effective means of achieving significant reductions in GHG emissions, even within a growing and affluent economy.