The context of intensified exploration for new reserves in Brazil, in view of the expected maturation of the pre-salt fields, sets precedents for the risk of energy insecurity. The Brazilian Equatorial Margin region, especially its Amazonian portion, plays an important role in this scenario, due to the discovery of large volumes of oil and gas in Guyana, Suriname and French Guiana, which is around 50 km from the Amapá border. This has motivated oil and gas companies to start their exploration activities in the region. However, the Foz do Amazonas Basin, the closest to the Guyana-Suriname Basin, is in an environmentally, socially, and economically sensitive region. This makes the need to map as many of the impacts associated with the project as possible, and to identify measures to mitigate negative impacts, even more relevant. This research therefore identifies the opportunities, the possible negative impacts of oil and gas exploration in the region, and the alternatives for mitigating them.