Antihypertensive activity of farnesol in Goldblatt hypertensive rats (2K-1C)

Antihypertensive activity of farnesol in Goldblatt hypertensive rats (2K-1C)

• Autor
• Gabriela Dantas Carvalho
• Co-autores
• Moises Tolentino Bento da Silva , Lucindo José Quintans Júnior , Adriano Antunes de Souza Araújo , Lucas Vaz de Castro Oliveira , Rômulo Barros dos Santos , João Paulo Jacob Sabino , Aldeídia Pereira de Oliveira
• Resumo

• INTRODUCTION: Hypertension has a multifactorial etiology, with the humoral system as one of the control mechanisms. The aim of this study was to evaluate the antihypertensive effect of farnesol in a 2K-1C hypertensive model. METHODS: Wistar rats (220-300g), normotensive, from the vivarium at UFPI (CEUA/UFPI nº 549/2019/Resolution nº 1000/2012) were used. For the induction of hypertension (2K-1C) followed Goldblatt et al., (1934). Monitoring the development of hypertension was obtained by recording Systolic Blood Pressure (SBP) by tail plethysmography (Narco Bio-Systems, USA) for 6 weeks. The hypertensive groups and controls underwent catheterization of the left femoral artery and vein for direct measurement of mean arterial pressure (MAP) and heart rate (HR) (Mendes et al., 2014). The venous catheter was used to administer doses of farnesol (6;12.5;25 mg/kg, i.v.) and atropine (2 mg/kg, i.v.). Results expressed as (mean ± s.e.m, One-way Anova analysis, P values <0.05, significant - Prism 6.0). RESULTS: The 2K-1C animals presented SBP values of (161.54 ± 1.86 mmHg) and HR (331.25 ± 2.11, bpm). Farnesol promoted PAM antihypertensive effect (-30.71 ± 6.38*; -26.05 ± 3.17; -51.13 ± 3.18 mmHg, n=6), followed by bradycardia HR (- 56.31 ± 2.72***; -59.86 ± 0.95***; -73.67 ± 1.79*** bpm, n=6) in all doses (6;12.5 ;25 mg/kg), respectively. After pretreatment with atropine (2mg/kg), an attenuation of the farnesol effect was observed only at 25 mg/kg (MAP: -14.90 ± 3.77; -15.72 ± 3.29; - 30.45 ± 5.58*, n=5) and (FC: -54.89 ± 8.25; -52.19 ± 6.72; -41.90 ± 9.79*, n=5). CONCLUSION: Farnesol has an antihypertensive effect and a reduction in heart rate, with involvement of muscarinic receptors.

• Palavras-chave
• Farnesol, antihypertensive, blood pressure
• Área Temática
• Vídeo-pôster / Sala 5 - Farmacologia do Sist. Cardiovascular

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