Cardiac alterations in a preclinical model of nonalcoholic fatty liver disease.

Cardiac alterations in a preclinical model of nonalcoholic fatty liver disease.

• Autor
• Vivian Vieira Dias da Silva
• Co-autores
• Karine Lino Rodrigues , Evelyn Nunes Goulart da Silva Pereira , Raquel Rangel Silvares , Edgar Eduardo Ilaquita Flores , Beatriz Peres de Araujo , Isalira Peroba Ramos , Anissa Daliry
• Resumo

•  

  Cardiac alterations in a preclinical model of nonalcoholic fatty liver disease.

   

  Vivian Vieira Dias Da Silva, Karine Lino Rodrigues, Evelyn Nunes Goulart da Silva Pereira, Raquel Rangel Silvares, Edgar Eduardo Ilaquita Flores, Beatriz Peres de Araujo, Isalira Peroba Ramos and Anissa Daliry.

   

  Summary

  Introduction

  Non-alcoholic fatty liver disease (NAFLD) affects 20-30% of the adult population worldwide. Studies suggest an important causal relationship between liver changes and cardiovascular diseases, which is the main cause of death in patients with NAFLD. However, the underlying mechanisms that lead to cardiac dysfunction in NAFLD are not fully understood. Despite its importance, few animal model that fully replicates the cardiac alterations associated to NAFLD in the human disease and suitable to predict therapies efficacy in humans are available. Therefore, the objective of this study was to establish a preclinical NAFLD model that present cardiac dysfunction.

  Methods

  C57BL/6 mice were fed a high-fat, high-carbohydrate diet (HCHF) composed of 55% kcal of fat associated with the addition of 250 g/L of fructose in drinking water or a normocaloric diet (CTL) for 36 weeks. At the end of the protocol, the body weight, biochemical markers, severity of steatosis, presence of fibrosis and cardiac function were evaluated.

  Results

  HCHF mice showed increased body weight, and hepatic steatosis and fibrosis when compared to CTL. Regarding cardiac damage, the HCHF group showed a decrease in the heart's pumping capacity when compared to the CTL group, as shown by decreased  stroke volume, ejection fraction and cardioprotective index. A negative correlation was observed between cardiac alterations and steatosis/fibrosis parameters.

  Conclusion

  We conclude that the present diet induced NAFLD model is a suitable preclinical model for the study of the cardiac alterations associated with NAFLD.

   

   

   

  XXVI Simpósio Brasileiro de Fisiologia Cardiovascular, 10-11 de março de 2022, BH/MG. On-line.  

• Palavras-chave
• Non-alcoholic fatty liver disease, cardiac, alterations
• Área Temática
• Vídeo-pôster / Sala 1 - Fisiologia Cardíaca

Voltar