THE IMPACT OF THERAPEUTIC HYPOTHERMIA ON
NEWBORNS WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY
ABSTRACT: Objective: to express the physiological and biochemical effects of therapeutic hypothermia (TH) in the evolution of hypoxic-ischemic encephalopathy (HIE), to present the selection criteria for neonates that are candidates for therapy, to expose the standard clinical procedure of the technique and, lastly, to reveal the TH role in morbimortality rate, and in the cognitive and motor development of newborn with HIE, making evident the possible adverse effects of therapy. Methods: A bibliographic survey was carried out in the LILACS, SciELO and PubMed databases, of renowned scientific articles with a publication interval between 1997-2020 on the theme of HT in newborns with EHI. After aplying inclusion and exclusion criteria 25 articles were analyzed and divided into 11 bibliographic reviews, 10 experimental studies, 1 systematic review with meta-analysis and 3 case control studies, in order to understand the impact of HT and its neuroprotective hypothesis. Conclusion: As long as performed by a qualified professional team e following precisely the application protocol, the TH acted in the reduction of damage due to HIE in newborn, especialy in mild and moderate stages, softening brain lesion, favoring a good neurological outcome and great prognosis.
Keywords: Fetal Hypoxia; Hypoxia-Ischemia, Brain; Brain diseases; Hypoxia, Brain; Hypothermia, Induced.
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