Ozone therapy as a promising treatment for fibromyalgia: an integrative literature review
ABSTRACT
The fibromyalgia is a rheumatic syndrome that affects approximately 2% of the Brazilian population. The referred one, is characterized, mainly, by generalized chronic pain and by specific painful areas called tender points. However, it may have other associated symptoms such as changes in sleep quality, debility, stiffness in the morning, changes in mood, memory and concentration, among others. Bearing in mind that oxidative stress is the most accepted etiology, ozone therapy is a possible effective treatment, which justifies its application and evaluation. Furthermore, the objective of this paper is to evaluate the use of ozone therapy in the treatment of fibromyalgia. As this is an integrative literature review, it was used as methodology the selection of articles on the BVS, PubMed and Google Scholar platforms with the keywords: fibromyalgia, ozone therapy and treatment. The selection criteria were published between 2010-2020 in Portuguese, English or Spanish and complete, preferably which resulted in the selection of 20 articles in total. Therefore, research shows that ozone promotes a mild, transient and regulated oxidative stress capable of inducing the activity of the antioxidant and immune systems. Clinical trials conducted between 2010 and 2019 using ozone therapy through the techniques of rectal insufflation, autohemotransfusion, subcutaneous injection and application of intravenous saline solution with a number of varied sessions indicate several benefits. Due to this therapy, there is a decrease in lipid peroxidation (LP), carbonyl protein content (PC) and generation of reactive oxygen species (ROS) indicating a general reduction in oxidative stress. Jointly, there was an improvement in the FIQ (Fibromyalgia Impact Questionnaire) and several complaints frequently presented as pain, depression, sleep disorders and anxiety. Hence, it is concluded that the use of ozone therapy to treat fibromyalgia is auspicious due to its several positive results and improvement in the patient's quality of life. Therefore, it is of utmost importance to carry out further investigations, checking the possible limitations and long-term side effects.
KEYWORDS: Fibromyalgia. Ozone therapy. Treatment.
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