Liquid biopsy applying infrared absorption spectroscopy represents a new non-invasive approach that has been widely studied in the last decade and holds great promise to contribute to the diagnosis, especially in diseases such as oral cancer, which affects more than 377,000 people worldwide. In this work, saliva from patients with squamous cell carcinoma and patients without the pathology was subjected to micro-reflectance infrared absorption spectroscopy to identify their spectral signatures, compare them, observe the separation of the study groups, and discover biomarkers of oral cancer. Statistical analysis showed that the accuracy was greater than 90%, and with the ROC curve, we observed the main spectral changes in the bands at 883, 898, 1770, 1818, 1855, and 1878 cm-1 which correspond to the biomolecules histidine and 2-Keto adipic acid, palmitic acid, and acetoacetic acid laid biomolecules, which are commonly increased in people with cancer.
Bem-vindo(a) aos Anais do VII NanoMat, evento organizado pela Pós-graduação em Nanociências e Materiais Avançados da Universidade Federal do ABC (UFABC) com o intuito de reunir e debater trabalhos desenvolvidos por alunos e pós-doutorandos em Materiais e áreas afins.
Comissão Organizadora
Pedro Alves da Silva Autreto
Andre Luiz Martins de Freitas
Aryane Tofanello
Comissão Científica
Ferramenta completa de submissão, avaliação e publicação de anais para eventos científicos.
