A wound is a disturbance of the tissue''s standard shape and function. Skin disruption happens in skin lesions due to physical, thermal, or chemical damage or certain underlying medical or pathological conditions. Gram-positive, sphere-shaped bacteria such as Staphylococcus aureus are a significant health issue due to their multidrug resistance (MDR). Methods for delivering bactericides straight to incisions are being researched. Chemical and photochemical compounds such as safranin and phenothiazines are excellent options for attacking bacteria through chemical and photochemical mechanisms. However, the water solubility and rapid release restrict their effectiveness. In this study, a new hybrid biomaterial was created that combines bacterial cellulose (BC) hydrogel and cellulose nanofibers (CNF) for use as a local drug delivery implant for skin treatments using safranin, which has excellent antimicrobial action against Gram-positive bacteria. CNF increased the safranin load by around two times more than safranin only incubated in BC, indicating a kinetically controlled release mechanism. Bacterial cellulose was also efficient in adsorbing phenothiazine radical cation and its corresponding oligomer, which is promising for application in photodynamic therapy.
Bem-vindo(a) aos Anais do VII NanoMat, evento organizado pela Pós-graduação em Nanociências e Materiais Avançados da Universidade Federal do ABC (UFABC) com o intuito de reunir e debater trabalhos desenvolvidos por alunos e pós-doutorandos em Materiais e áreas afins.
Comissão Organizadora
Pedro Alves da Silva Autreto
Andre Luiz Martins de Freitas
Aryane Tofanello
Comissão Científica
Ferramenta completa de submissão, avaliação e publicação de anais para eventos científicos.
