The cardiotonic steroid digoxin, BD-8, evaluated on this study, is a compound that as which as other digoxin derivatives, shows a great potential on the increase of the activity of the Na,K,Pump, focusing the search of new compounds that are involved as potential treatments of neurodegenerative diseases. On this study, we evaluated on the hippocampus of Wistar Rats, which would be the best concentration of BD-8, on behavioral parameters and biochemicals, such as the evaluation of the Na,K,Pump and GSH content, in order to select the best dose for later studies. The animals used in this study were Wistar Rats being an N=6, totalizing 30 animals, which were separated into five groups, control, 20?g/kg, 100?g/kg, 200?g/kg e 400?g/kg. The application was carried out for 3 days, within a 24-hour interval during the applications, and the administration applied intraperitoneally (IP). The activity of the Na,K,Pump and GSH were evaluated. In none of the biochemical parameters tested was it possible to observe significant changes when compared to the control group. The total activity of Na,K,Pump increased by 17,24% at a dose of 400?g/kg. As for ?1 we observed an increase of 33,6% at a dose of 200?g/kg. And in relation to ?2,3 we observed an increase of 22,4% also at a dose of 400?g/kg. The GSH content at a dose of 200?g/kg showed an increase of 10,76%. The behavioral analysis also did not demonstrate changes when compared to the control group. Finally, from these data it’s possible to observe that all doses tested are safe for next studies on different models, aiming to find a promising treatment for neurodegenerative diseases.
Dear Colleagues and Friends,
We are thrilled to extend a warm welcome to the 8th Annual Meeting of the Cardiotonic Steroids and Na Pump, in collaboration with the Brazilian Society of Pharmacology and Experimental Therapeutic Society (SBFTE) and the Brazilian Society for Biochemistry and Molecular Biology (SBBq). The event is scheduled to take place at the Federal University of São João del Rei (UFSJ) from August 20th to 23rd, 2024.
The Na pump meeting stands as one of Brazil's most enduring scientific gatherings. Over the past decade, it has been hosted by various Brazilian institutions, serving as a pivotal platform for scientific discussions that contribute significantly to the advancement of fundamental knowledge in Na, K-ATPase biochemistry, molecular biology, and related fields. Additionally, it serves as a forum for dialogues on scientific education and training, generating consensus that can influence public policies for the betterment of society.
For this year's meeting, the organizing committee has curated an engaging interdisciplinary program, featuring lectures by esteemed foreign scientists. These sessions will delve into the latest advancements and current challenges across a broad spectrum of research topics in Biochemistry and the Molecular Na pump signaling cascade.
We eagerly anticipate your participation in this exciting scientific event and hope to see you soon in Minas Gerais!
Best regards,
Scientific Committee
Comissão Organizadora
Dr Leandro Augusto Barbosa
Dr Vanessa Faria Cortes
Sílvia Ramos Silva
Marina Vieira
Anna Karolina de Oliveira Alfenas Gadelha - Mídias Sociais e Papelaria
Jessica Alves Faria - Coffee Break e Gráfica
Lucas Antônio Lisboa Ribeiro - Apresentação/Cerimonial
Poliana Amorim Santos - Abertura/ Encerramento/ parte recreativa
?Ana Gabriela Finamore dos Santo-Midias Sociais e Suporte Técnico.
Thiago Malverde de Oliveira - Divulgação (SJDR) e suporte
Maurício Gustavo Oliveira - Credenciamento
Ítalo Leonardo Diogo - Contato com a pós-graduação e Controle de Frequência
Julia Lopes Granato - Midias sociais e controle de frequência
Comissão Científica
Dr. Gustavo Blanco – Kansas University Medical Center, USA
Dr. John Hamlyn – University of Maryland, USA
Dr. Rúben Gerardo Contreras Patiño – CINVESTAV, Mexico
Dra. Vanessa Faria Cortes - Federal University of São João del-Rei, Brazil
Dr Carlos Frederico Leite Fontes - Federal University of Rio de Janeiro, Brazil
Dr Cristoforo Scavone - University of Sao Paulo
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