Melatonin, provided by the mother to the fetus during development, acts as an antioxidant in crucial nervous system cellular processes. Valproic acid (VPA), used during pregnancy, serves as a model for Autism Spectrum Disorder (ASD) studies. This research investigated if the absence of maternal melatonin causes similar offspring damage as VPA exposure during intrauterine development. Wistar rats were divided into five groups: pinealectomized with and without melatonin supplementation, SHAM (surgical procedure without pineal removal), VPA injection on gestation day 13, and saline injection as a VPA control. After four weeks, offspring were sacrificed, and their livers were analyzed for glucose, triglycerides, cholesterol, Na+,K+-ATPase activity, and hepatocyte antioxidant system integrity via GSH, MDA, and H2O2 measurements. Results showed no significant differences in Na+,K+-ATPase activity between VPA-exposed, melatonin-deficient, and control groups, despite trends indicating potential damage. However, significant differences in H2O2 and GSH levels were observed in the VPA group compared to the saline group, with an increase in H2O2 in the melatonin-deficient group compared to the SHAM group. This suggests specific impacts on the hepatocyte antioxidant system. Histological analyses revealed no significant liver tissue morphological changes in offspring exposed to VPA or melatonin compared to the control group. This indicates that ion transport function remains unaffected, while the hepatic antioxidant system is influenced by these substances. In conclusion, this study provides insights into the effects of maternal exposure to exogenous substances during pregnancy, emphasizing the need for further research to understand these exposures' mechanisms and consequences on offspring health.
Dear Colleagues and Friends,
We are thrilled to extend a warm welcome to the 8th Annual Meeting of the Cardiotonic Steroids and Na Pump, in collaboration with the Brazilian Society of Pharmacology and Experimental Therapeutic Society (SBFTE) and the Brazilian Society for Biochemistry and Molecular Biology (SBBq). The event is scheduled to take place at the Federal University of São João del Rei (UFSJ) from August 20th to 23rd, 2024.
The Na pump meeting stands as one of Brazil's most enduring scientific gatherings. Over the past decade, it has been hosted by various Brazilian institutions, serving as a pivotal platform for scientific discussions that contribute significantly to the advancement of fundamental knowledge in Na, K-ATPase biochemistry, molecular biology, and related fields. Additionally, it serves as a forum for dialogues on scientific education and training, generating consensus that can influence public policies for the betterment of society.
For this year's meeting, the organizing committee has curated an engaging interdisciplinary program, featuring lectures by esteemed foreign scientists. These sessions will delve into the latest advancements and current challenges across a broad spectrum of research topics in Biochemistry and the Molecular Na pump signaling cascade.
We eagerly anticipate your participation in this exciting scientific event and hope to see you soon in Minas Gerais!
Best regards,
Scientific Committee
Comissão Organizadora
Dr Leandro Augusto Barbosa
Dr Vanessa Faria Cortes
Sílvia Ramos Silva
Marina Vieira
Anna Karolina de Oliveira Alfenas Gadelha - Mídias Sociais e Papelaria
Jessica Alves Faria - Coffee Break e Gráfica
Lucas Antônio Lisboa Ribeiro - Apresentação/Cerimonial
Poliana Amorim Santos - Abertura/ Encerramento/ parte recreativa
?Ana Gabriela Finamore dos Santo-Midias Sociais e Suporte Técnico.
Thiago Malverde de Oliveira - Divulgação (SJDR) e suporte
Maurício Gustavo Oliveira - Credenciamento
Ítalo Leonardo Diogo - Contato com a pós-graduação e Controle de Frequência
Julia Lopes Granato - Midias sociais e controle de frequência
Comissão Científica
Dr. Gustavo Blanco – Kansas University Medical Center, USA
Dr. John Hamlyn – University of Maryland, USA
Dr. Rúben Gerardo Contreras Patiño – CINVESTAV, Mexico
Dra. Vanessa Faria Cortes - Federal University of São João del-Rei, Brazil
Dr Carlos Frederico Leite Fontes - Federal University of Rio de Janeiro, Brazil
Dr Cristoforo Scavone - University of Sao Paulo
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