Vascular Dysfunction In Experimental Models Of Type 2 Diabetes Mellitus In Rats: A Systematic Review

Vascular Dysfunction In Experimental Models Of Type 2 Diabetes Mellitus In Rats: A Systematic Review

• Autor
• Everton de Oliveira Pinto
• Co-autores
• Nayana Yared Batista , Felipe Rodolfo Pereira da Silva , Alessandro Luiz Araújo Bentes Leal , Silvania da Conceição Furtado , José Fernando Marques Barcellos , José Wilson do Nascimento Corrêa
• Resumo

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  Aim: The study of vascular dysfunction in type 2 diabetic rats has been carried out in different models, as by induction or conducted in genetic modified animals. To ensure the better comparison of obtained results, this systematic review aimed to identify protocols that presents a pattern of initiation and development of diabetes and, consequently, reliable and homogeneous results on vascular dysfunction.

  Methods: A protocol for the elaboration of systematic reviews was carried out, in which two calibrated researchers conducted a literature search for articles published and framed in predefined criteria. After the screening, 30 studies were adapted to the proposal of the present study. In vascular reactivity protocols, endothelial function was analyzed in induced or naturally (genetic model) diabetic rats.

  Results: The genetic animal models for diabetes were frequently used, but the induction methods associated with streptozotocin administration was more prevalent in the studies. The induction with low doses of streptozotocin in combination with oral fructose or a high-fat diet present the highest percentage and less variable vasodilator impairment, 47.57 ± 3.8% and 44.40 ± 13.8%, respectively, when compared to non-diabetic animals. The genetic models or those induced with a high dose of streptozotocin present less significant or more variable endothelial dysfunction, 24.4 ± 3.89% and 23.37 ± 17.15%, respectively.

  Conclusion:  Type 2 diabetic models induced with low doses of streptozotocin in combination with a high-fat diet or oral fructose administration provide a more reliable way of conducting vascular dysfunction studies in rats.

• Palavras-chave
• Type 2 Diabetes Mellitus; Vasodilation; Animal models.
• Modalidade
• Pôster
• Área Temática
• Revisões, projetos, revisões sistemáticas e metanálises em biologia vascular