Coagulopathy Acts as a Risk Factor for Mortality in Patients with COVID-19: Systematic Review and Metanalysis

Coagulopathy Acts as a Risk Factor for Mortality in Patients with COVID-19: Systematic Review and Metanalysis

• Autor
• Liliane Emilly dos Santos Sousa
• Co-autores
• Antonio Márcio Teodoro Cordeiro Silva , Jacqueline Andreia Bernardes Leão-Cordeiro
• Resumo

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  Introduction: Coronavirus Disease 2019 (COVID-19), is a disease caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome, Coronavirus 2). The presence of coagulopathy is one of the complications in patients with COVID-19, which are associated with a higher risk of hospitalizations and mortality due to the disease. Objective: To evaluate the association of coagulopathy with the risk of mortality, by COVID-19. Methods: It is a systematic review with meta-analysis, based on scientific articles, published in English, in 2020, indexed in the databases: PubMed (n=137) and ScienceDirect (n=49), using the descriptors: “Comorbidities” “cardiovascular diseases” “diabetes” “hypertension” “patients” “infection” “coronavirus” “SARS-CoV-2” and “COVID-19”. Four studies were selected, which associated the presence of coagulopathy with mortality, due to COVID-19, in patients who died (n=167) and survived (n = 298). 182 articles were excluded for presenting: methodological design different from the proposed study (n = 175) and duplication in the consulted databases (n=7). For the statistical analysis, the BioEstat 5.3 Software was used, applying the tests: heterogeneity Chi-square, DerSimonian-Laird and Mantel-Haenszel, with a significance level of up to 5% (p-value < 0.05). Results: 465 patients with COVID-19 were analyzed. Among these individuals, 12.5% ??had coagulopathy, according to a complication resulting from COVID-19. Thus, the presence of coagulopathy, acts as a causal factor of mortality (OR = 13.801; 95% CI = 6.550-29.076; p <0.0001) increasing the risk of the patient, with COVID-19, to evolve by approximately 13 times. to death. Conclusion: Coagulopathy, acts as one of the clinical complications, which may be present in hospitalized patients with severe COVID-19, which is associated with a higher risk of mortality. In this context, the early diagnosis of the disease, added to the supportive treatment, allows to reduce the aggravations in the clinical symptomatic of patients, and, in situations of complications and mortality, by COVID-19.

• Palavras-chave
• Blood Coagulation Disorders, Coronavirus Infection, Mortality
• Modalidade
• Pôster
• Área Temática
• COVID-19 e complicações vasculares