Oncology 2025 - Anais

Molecular Studies - 41

A SINGLE-CELL AND SPATIAL TRANSCRIPTOMICS-INFORMED APPROACH FOR TUMOR ANTIGEN PRIORITIZATION IN IMMUNE CHECKPOINT BLOCKADE COHORTS

André Fonseca

Molecular Studies Tumor antigens; single-cell RNA-seq; spatial transcriptomics; tumor microenvironment.

ANALYSIS OF mTOR PATHWAY EXPRESSION IN ORTHOFLAVIVIRUS ILHEUSENSE (ILHÉUS) INFECTION IN GLIOBLASTOMA

Alex Santos Guedes , Bruna Caldas de Souza , Fabiane Diniz Machado Vilhena , Gabriela Santos da Cruz , Joyhare Barbosa Souza , Karina Glazianne Barbosa Carvalho , Nila de Nazaré Brito Domingues Cidon , Samir Mansour Moraes Casseb

Molecular Studies Oncolytic Viruses; Orthoflavivirus ilheusense; mTOR Signaling; microRNAs; Glioblastoma

ANALYSIS OF THE CO-EXPRESSION OF THE CDH17 AND CDX2 GENES IN PATIENTS DIAGNOSED WITH GASTRIC CANCER IN THE STATE OF PARÁ

Bianca de Fátima dos Reis Rodrigues , Fabiano Cordeiro Moreira , Jade Dias Valente , Jessica Manoelli Costa da Silva , Livia Erika Carlos Marques , Myrth Soares do Nascimento Remígio , Paulo Pimentel de Assumpção

Molecular Studies Gastric cancer; CDH17 CDX2 biomarkers.

APPLICATION OF RANDOM FOREST AND LASSO ALGORITHMS FOR BIOMARKER DISCOVERY IN NON-SMALL CELL LUNG CANCER SUBTYPES

Camila Tavares Carvalho Uchôa , Diego Pereira , Fabiano Cordeiro Moreira , Jessica Manoelli Costa da Silva , Lorena Duarte Fernandes , Paulo Pimentel Assumpção , Ronald Matheus da Silva Mourão , Samir Mansour Casseb , Sérgio Augusto Antunes Ramos , Valéria Cristiane Santos da Silva

Molecular Studies Lung cancer; Random Forest; LASSO

ASSOCIATION OF INDEL POLYMORPHISMS IN PIRNA CODING REGIONS WITH SUSCEPTIBILITY TO ACUTE LYMPHOBLASTIC LEUKEMIA

Ândrea Ribeiro-dos-Santos , Caio Silva , Camila Esdra Batista Chaves , Camille Sena dos Santos , Catarine Mendes Santos , Fabiano Cordeiro Moreira , Georgia Maria de Holanda Miranda , Jhully Azevedo dos Santos Pinheiro , Maria Eduarda da Silva Pereira , Sidney Emanuel Batista dos Santos

Molecular Studies INDEL; piRNA; acute lymphoblastic leukemia.

ASSOCIATION OF THE MOLECULAR PROFILE OF THE TTN GENE WITH PREDISPOSITION TO GASTRIC CANCER IN A POPULATION FROM NORTHERN BRAZIL.

ANA CLARA ARAUJO DOS SANTOS , André Maurício Ribeiro-Dos-Santos , Ândrea Ribeiro-Dos-Santos , Juliana Carla Gomes Rodrigues , Letícia Silva Carneiro , Marianne Rodrigues Fernandes , Ney Pereira Carneiro Dos Santos , Patrícia Rodrigues Portugal , Rommel Mario Rodriguez Burbano da Silva , Sidney Emanuel Batista Dos Santos

Molecular Studies Predisposition genetic; Gastric cancer; TTN gene; Northern Brazil.

BACTERIOPHAGES OF HELICOBACTER PYLORI IDENTIFIED IN GASTRIC CANCER SAMPLES FROM THE STATE OF PARÁ

Fabiano Cordeiro Moreira , Jessica Manoelli Costa da Silva , Karina Glazianne Barbosa Carvalho , Paulo Pimentel de Assumpção , Samir Mansour Moraes Casseb , Sidney Emanuel Batista dos Santos

Molecular Studies Gastric cancer; Bacteriophages; Helicobacter pylori.

CHARACTERIZATION OF CDK7 GENE VARIANTS ASSOCIATED WITH CANCER IN AMERINDIANS OF THE BRAZILIAN AMAZON

Amanda de Nazaré Cohen-Paes , Darlen Cardoso de Carvalho , Débora Monteiro Carneiro do Vale , Diego Di Felipe Ávila Alcântara , Elisa da Silva Meneses , João Farias Guerreiro , Kezia Nascimento Góes , Marianne Rodrigues Fernandes , Ney Pereira Carneiro dos Santos , Rommel Mario Rodriguez Burbano

Molecular Studies CDK7; Amerindian populations; cancer susceptibility.

CHARACTERIZATION OF REGULATORY GENOMIC REGIONS AND TRANSCRIPTION FACTORS IN PRIMARY COLON CANCER

Danielle Queiroz Calcagno , Guilherme Cardoso Almada , Isabela Erthal , Juscelino Carvalho de Azevedo Junior , Tathiane Maistro Malta

Molecular Studies Epigenetic modification; Methylome; Molecular targets.

CHARACTERIZATION OF UGT FAMILY GENES IN AMAZON INDIGENOUS POPULATIONS

André Maurício Ribeiro-dos-Santos , Ândrea Ribeiro-dos-Santos , João Farias Guerreiro , Juliana Carla Gomes Rodrigues , Luciana Pereira Colares Leitão , Natasha Monte , Ney Pereira Carneiro dos Santos , Sandro José de Souza , Sidney Santos

Molecular Studies Anthracyclines; amazonian indigenous; phamacogenomics

COMPREHENSIVE ANALYSIS OF THE MUTATIONAL LANDSCAPE IN GASTRIC ADENOCARCINOMA TRANSCRIPTOMES FROM THE STATE OF PARÁ

Daniel de Souza Avelar da Costa , Diego Pereira , Fabiano Cordeiro Moreira , Jéssica Manoelli Costa da Silva , Kelly Cristina da Silva Oliveira , Paulo Pimentel de Assumpção , Rommel Rodríguez Burbano , Rubem Ferreira da SIlva , Samia Demachki , Valéria Cristiane Santos da Silva

Molecular Studies Keywords: Gastric cancer Biomarkers Mutational signatures

CYTOGENOMIC CHARACTERIZATION OF THE HCT-8 COLORECTAL ADENOCARCINOMA CELL LINE

Edivaldo Herculano Correa de Oliveira , Gabriel Ferreira Leite , Rodrigo Petry Corrêa de Sousa

Molecular Studies aCGH; CNAs; In vitro model.

DETECTION OF COLORECTAL CANCER BIOMARKERS FROM TUMOR-EDUCATED PLATELET RNA USING MACHINE LEARNING

Ana Beatriz Lima Belicha , Danielle Queiroz Calcagno , Felipe Mateus Souza Serrão , Guilherme Cardoso Almada , Juscelino Carvalho de Azevedo Júnior , Valéria Cristiane Santos da Silva

Molecular Studies precision medicine; liquid biopsy; tumor-educated platelets; machine learning; gene expression.

EVALUATION OF COPY NUMBER CHANGES (CNAs) IN THYROID NEOPLASMS

Edivaldo Herculano Correa de Oliveira , Joseane Pereira Honorato , Patricia da Costa Moda Celso

Molecular Studies Thyroid; Neoplasms; CNAs; aCGH; Benign tumors; Malignant tumors.

Evatuation of ANPEP/CD13 as a Biomarker of Gastric Premalignant Lesions

Ana Karyssa Mendes Anaissi , Fabiano Cordeiro Moreira , Juliana Barreto Albuquerque , Mateus Silva Tavares , Paulo Pimentel de Assumpção , Rommel Rodríguez Burbano , Samia Demachki , Taíssa Maíra Thomaz Araújo , Thaynara Pereira de Abreu , Williams Fernandes Barra

Molecular Studies Autoimmune atrophic gastritis Metalplasia Gastric cancer ANPEP/CD13 Carcinogenesis

EXPRESSION ANALYSIS OF THE CTCFL/BORIS GENE IN GASTRIC CANCER PATIENTS FROM THE STATE OF PARÁ

André Salim Khayat , Bianca de Fátima dos Reis Rodrigues , Debora Cristina Viana Pereira , Fabiano Cordeiro Moreira , Jade Dias Valente , Jessica Manoelli Costa da Silva , Livia Erika Carlos Marques , Louise Sousa de Souza , Myrth Soares do Nascimento Remígio , Paulo Pimentel de Assumpção

Molecular Studies Gastric neoplasms; biomarkers; transcriptome.

EXPRESSION OF MYC/MAX/MAD AXIS IN GASTRIC ADENOCARCINOMA

Diego Pereira , Fabiano Moreira , Geraldo Ishak , Jéssica Costa , Juliana Pinto , Kauê Sant'Ana Pereira Guimarães , Paulo Assumpção , Ronald Mourão , Samia Demachiki , Samir Casseb

Molecular Studies Gastric cancer; Differential expression; Cancer transcriptomics; MYC/MAX/MAD network

EXPRESSION PROFILING OF NOVEL THERAPEUTIC TARGETS IN GASTRIC CANCER

Fabiano Cordeiro Moreira , Lívia Érika Carlos Marques , Louise Sousa de Souza , Paulo Pimentel de Assumpção , Polyana Silva de Araújo , Rommel Rodríguez Burbano , Samir Mansour Moraes Casseb , Taíssa Maíra Thomaz Araújo

Molecular Studies Gastric cancer Carcinogenesis Novel targets Therapy

EXPRESSION PROFILING OF PD-L1, LGALS9, TGFB1, AND HAV¬CR2 IN GASTRIC CANCER AND METAPLASIA: IMPLICATIONS FOR TARGETED THERAPIES AND PREVENTION OF MALIGNANT PROGRESSION

Ana Paula Freitas de Sousa

Molecular Studies Metaplasia Gastric cancer Carcinogenesis Novel targets Therapy

FUNCTIONAL -94 DEL/DEL ATTG POLYMORPHISM OF THE NFKB1 GENE AND RISK OF SEVERE ANEMIA IN CHILDREN WITH T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Alayde Vieira Wanderley , Amanda de Nazaré Cohen Paes , Daniel Damasceno de Campos , Darlen Cardoso de Carvalho , Débora Evelyn Ferreira Silva1 , Dilson Raimundo Gomes Pinheiro Neto , Ícaro Natan da Silva Moraes , Márcia Mayanne Almeida Bezerra , Ney Pereira Carneiro dos Santos , Tatiane Piedade de Souza

Molecular Studies T-cell Acute Lymphoblastic Leukemia NFKB1 Polymorphism Anemia.

GENE EXPRESSION PROFILE OF THE ABCA FAMILY IN GASTRIC CANCER: A STUDY USING RNA-SEQ

André Salim Khayat , Daniele de Araujo Moyses , Eliel Barbosa Teixeira , Fabiano Cordeiro Moreira , Gabriella Farias Galucio da Cruz Matos , Jéssica Manoelli Costa da Silva , LUCIETE PIMENTEL OLIVEIRA , Marcelo de Oliveira Bahia , Natasha Costa da Rocha Galucio , Paulo Pimentel de Assumpção

Molecular Studies Gastric cancer; ABCA; RNA-Seq;

GENETIC AND MORPHOLOGICAL CHARACTERIZATION OF A CELL LINE OF ADENOID CYSTIC CARCINOMA OF THE SALIVARY GLAND

Alessandra Santos dos Santos , Danielle Queiroz Calcagno , Fernanda Jardim da Silva , Juscelino Carvalho de Azevedo Júnior , Thais Ferreira da Silva

Molecular Studies Adenoid cystic carcinoma; Oral cancer; Molecular profiling; Targeted therapy.

GENOMIC PROFILE OF COLORECTAL TUMORS IN YOUNG ADULTS: A RETROSPECTIVE STUDY IN THE AMAZON REGION

VItória de Sena Magalhães

Molecular Studies Oncology; Genomic Ancestry; Somatic and Epigenetic Mutations.

IMMUNOHISTOCHEMICAL EXPRESSION PROFILE OF P16 AND P53 IN SAMPLES FROM PATIENTS WITH VULVAR CANCER

Ana Gabrielly de Melo Matos , Antonio Augusto Lima Teixeira Júnior , Denner Rodrigo Diniz Duarte , Gyl Eanes Barros Silva , Jaqueline Diniz Pinho , João Pedro Cruz Nascimento , João Victor Carvalho , Kwang Il Marciaga Teófilo , Leticia Milene Silva da Silva , Pedro Manuel Barros de Sousa

Molecular Studies Immunohistochemistry; Human Papillomavirus; Vulvar Neoplasms

IMMUNOMODULATORY AND ANTITUMOR EFFECTS OF BAICALEIN IN HUMAN NEUROBLASTOMA CELL LINES

Aline Collares Valente Pinheiro , Ana Paula Drummond Rodrigues , Diovanna Mirella dos Santos da Silva , Edivaldo Herculano C. de Oliveira , Fabiane Cristiny Trindade Alves , Felipe Tuji de Castro Franco , Maria Izabel de Jesus , Renato Lopes Fernandes de Medeiros , Sanderson Corrêa Araújo , Wallax Augusto Silva Ferreira

Molecular Studies Inflammatory cytokines; flavonoids; baicalein; neuroblastomas

INVESTIGATING KIAA0125 AS A MOLECULAR MARKER IN PEDIATRIC ACUTE LYMPHOID AND MYELOID LEUKEMIAS

Ágatha Tereza Miranda Tavares , Alayde Vieira Wanderley , André Salim Khayat , Bruna Cláudia Meireles Khayat , Cybelle Albuquerque de Miranda , Emerson Jhony Cruz Botelho , Laudreisa da Costa Pantoja , Lucas Brabo Rotella , Marcelo Braga de Oliveira , Márcio Santana de Aquino

Molecular Studies Acute Leukemia KIAA0125 Biomarker.

MICROBIOME-HOST INTERACTIONS MODULATED BY FLOT CHEMOTHERAPY IN GASTRIC ADENOCARCINOMA SUBTYPES: AN INTEGRATIVE APPROACH

Ana Karyssa Mendes Anaissi , Daniel de Souza Avelar da Costa , Dionison Pereira Sarquis , Fabiano Cordeiro Moreira , Jéssica Manoelli Costa da Silva , Mateus Silva Tavares , Paulo Pimentel de Assumpção , Rommel Rodríguez Burbano , Samia Demachki , Williams Fernandes Barra

Molecular Studies gastric cancer; tumor microbiome; FLOT Chemotherapy

miR-483-3p, miR-483-5p, and miR-514a-3p: NEW PROMISING BIOMARKERS FOR COLORECTAL CANCER

Ândrea Ribeiro-dos-Santos , Débora de Morais Cordeiro , Diego Marques da Costa Santos , Miguel Angel Cáceres-Durán , Rommel Mario Rodriguez Burbano , Thiago Maués Amaral

Molecular Studies CRC miRNAs Prognosis.

MMP FAMILY GENE EXPRESSION PROFILES AND THEIR CLINICOPATHOLOGICAL ASSOCIATIONS IN GASTRIC CANCER PATIENTS FROM PARÁ, BRAZIL

Ágatha Tereza Miranda Tavares , Aline Costa Bastos , André Salim Khayat , Emanuele Raimunda Louzada Moraes , Fabiano Cordeiro Moreira , Ingryd Nayara de Farias Ramos , Paulo Pimentel de Assumpção , Ronald Matheus da Silva Mourão , Samir Mansour Moraes Casseb , Viviane Ribeiro Santos

Molecular Studies MMPs; Gastric Cancer; RNA-seq

MMP FAMILY GENES AND PROTEIN INTERACTION NETWORKS IN GASTRIC CANCER: INSIGHTS FROM A BRAZILIAN COHORT

Ágatha Tereza Miranda Tavares , Aline Costa Bastos , André Salim Khayat , Cybelle Albuquerque de Miranda , Emanuele Raimunda Louzada Moraes , Fabiano Cordeiro Moreira , Paulo Pimentel de Assumpção , Ronald Matheus da Silva Mourão , Samir Mansour Moraes Casseb , Thaíssa Vitória Rodrigues Portal

Molecular Studies Gastric Cancer; MMP; Extracellular Matrix.

MOLECULAR PROFILE OF CDH1 GENE IN A MIXED-RACE POPULATION FROM THE BRAZILIAN AMAZON WITH GASTRIC CANCER

ANA CLARA ARAÚJO DOS SANTOS , ÂNDREA RIBEIRO-DOS-SANTOS , BRUNA MACEDO LOPES , JULIANA CARLA GOMES RODRIGUES , LAURA DE NAZARÉ MENDES RODRIGUES , MARCELO PIO DA SILVA TAVARES , MARIANNE RODRIGUES FERNANDES , NEY PEREIRA CARNEIRO DOS SANTOS , PATRICIA RODRIGUES PORTUGAL , SIDNEY EMANUEL BATISTA DOS SANTOS

Molecular Studies “CDH1”; “Gastric Cancer”; “Brazilian Amazon”

OVERVIEW OF lncRNA EXPRESSION IN NON-SMALL CELL LUNG CANCER REVEALS PATHWAYS FAVORABLE TO ADVANCE THE FIELD CANCERIZATION

Camila Tavares Carvalho Uchôa , Daniel de Souza Avelar da Costa , Fabiano Cordeiro Moreira , Jessica Manoelli Costa da Silva , Lorena Duarte Fernandes , Marcelli Geisse De Oliveira Prata Da Silva , Mariana Souza de Lima , Paulo Pimentel Assumpção , Samir Mansour Casseb , Sérgio Augusto Antunes Ramos

Molecular Studies Lung cancer transcriptomics lncRNA biomarkers biological pathways

PANEL OF POTENTIAL BIOMARKERS AND KEY MOLECULAR PATHWAYS IN CERVICAL CANCER

Fabiano Cordeiro Moreira , Leonardo Jacomo Valadares , Paulo Pimentel de Assumpção , W. M. Fong Amaris

Molecular Studies cervical cancer OncoKB biomarkers pathways homologous recombination Fanconi anemia

PHYLOGENETIC ANALYSIS OF THE LMP1 REGION OF EPSTEIN-BARR VIRUS IN CANCER PATIENTS FROM THE STATE OF PARÁ

Alex Santos Guedes , Bruna Caldas de Souza , Fabiane Diniz Machado Vilhena , Gabriela Santos da Cruz , Gisella da Costa Oliveira , Ian Eleres Carvalho da Silva , Karina Glazianne Barbosa Carvalho , Paulo Pimentel de Assumpção , Samir Mansour Moraes Casseb , Samuel Oliveira da Vera

Molecular Studies Neoplasms Molecular Diagnostic Techniques Epstein-Barr Virus Infections.

PIK3CA AS A PROGNOSTIC BIOMARKER IN CLEAR CELL RENAL CELL CARCINOMA: A BIOINFORMATIC ANALISYS

Clívia Vitória dos Santos da Silva , José Cleyton Nascimento Glins

Molecular Studies Tumor biomarkers; renal cell carcinoma; gene expression.

PIWIL1-REGULATED CANCER TESTIS ANTIGENS MAGEC3 AND MAGEA6 AS POTENTIAL TARGETS FOR ANTINEOPLASTIC IMMUNOTHERAPY

André Salim Khayat , Bruna Cláudia Meireles Khayat , Edivaldo Herculano Correa de Oliveira , Fabiano Cordeiro Moreira , Jade Dias Valente , Livia Érika Carlos Marques , Lucas Brabo Rotella , Paulo Pimentel de Assumpção , Taíssa Maíra Thomaz Araújo , Thaíssa Vitória Portal Rodrigues

Molecular Studies PIWIL1; Gastric cancer; Cancer-testis antigens

RAPID DIAGNOSIS OF HUMAN PAPILLOMAVIRUS (HPV) USING PCR-LAMP A POINT-OF-CARE APPROACH

Molecular Studies PCR-LAMP; Human Papillomavirus; Point-of-Care Diagnosis

SUBTYPE-SPECIFIC EXPRESSION AND COEXPRESSION PATTERNS OF CFTR IN GASTRIC CANCER

Camila Sinimbú Forte , Gilderlanio Santana de Araújo , Marcella Vitória Belém Souza

Molecular Studies CFTR; Gastric cancer; Gene expression; Co-expression networks.

TP53 MUTATIONS IN BREAST CANCER: ASSOCIATIONS WITH HISTOLOGICAL AND MOLECULAR SUBTYPES.

Ândrea Ribeiro dos-Santos , Helenize Catarina Moreira Costalat , Lui Wallacy Morikawa Souza Vinagre , Ricardo Cunha de Oliveira

Molecular Studies Breast Cancer TP53 TCGA Molecular Subtypes.

TRANSCRIPTIONAL SIGNATURES OF FIELD CANCERIZATION IN GASTRIC CANCER

Daniel de Souza Avelar Costa , Diego Pereira , Fabiano Cordeiro Moreira , Jessica Manoelli Costa da Silva , Paulo Pimentel de Assumpção , Ronald Matheus da Silva Mourão , Rubem Silva , Samia Demachki , Valeria Cristiane Santos da Silva , Williams Barra

Molecular Studies Field Cancerization Gastric Adenocarcinoma Deep learning

TUMOR-EDUCATED PLATELETS AS A MINIMALLY INVASIVE SOURCE OF BIOMARKERS OF BREAST CANCER DIAGNOSIS

Danielle Queiroz Calcagno , Felipe Mateus Souza Serrão , Fernanda Jardim da Silva , Guilherme Cardoso Almada , João Vitor Amaral Magalhães , Juscelino Carvalho de Azevedo Junior , Tamires Ferreira da Silva , Valéria Cristiane Santos da Silva

Molecular Studies Tumor-educated platelets biomarkers diagnosis liquid biopsy.

Voltar

It is with great enthusiasm that we present the Annals of the Oncology International Symposium 2025, an event that continues to solidify its significance in the oncology landscape of northern Brazil. Held in Belém, Pará, Oncology 2025 centered around the theme "The cancer control challenge: better knowing it to best facing it," dedicating itself to exploring the latest frontiers in cancer treatment and prevention.

This year, the symposium provided a deep dive into the essential role of knowledge in the fight against cancer, presenting new perspectives and scientific advancements across various areas of oncology. Renowned global experts gathered to share their most recent research and innovative approaches, offering participants a comprehensive view of the challenges faced by healthcare professionals and patients worldwide.

Presentations and discussions during the event focused on critical topics such as the use of new technologies, advancements in personalized therapies, and more effective prevention strategies. Additionally, particular attention was given to the unique challenges faced by the Amazon region, with efforts aimed at developing region-specific solutions to meet local needs.

Beyond being a high-caliber academic event, Oncology 2025 stood out as a moment for integration and professional networking, with the warm hospitality of the city of Belém offering participants a unique experience. This event became a platform for exchanging ideas, where science, culture, and humanity came together in pursuit of a common goal: to improve cancer control both in Brazil and globally.

This collection of abstracts and articles presented during the event reflects the ongoing dedication to research and the development of innovative solutions, highlighting the importance of collaboration and shared knowledge in the fight against cancer.

General Submission Guidelines:

The presenting author, who does not have to be the first author, must be registered for Oncology 2025.
Each abstract may have up to 10 authors, including the main author and co-authors.
Only original, unpublished work will be accepted.
Submissions must be related to oncology. However, project descriptions, work proposals, experience reports, and literature reviews will not be considered.
Clinical case reports are allowed, provided the abstract addresses scientific questions, details clinical observations, and includes primary scientific data.
The abstract must be written in English, but presentations may be given in Portuguese.
Abstracts must be between 300 and 500 words.

Molecular Studies
Experimental Research or Clinical Research
Case Report or Epidemiology
Others