2nd Brazil France Symposium on Medicinal Chemistry - Anais

Drug Design and Discovery, Synthesis and Natural Products - 45

STUDIES BASED ON NEGLECTED DISEASES - EVALUATION OF TERPENE ACTIVITY AS A POSSIBLE ANTIPARASITARY AGENT: A PHARMACOLOGICAL OVERVIEW

Helen Raynara Dantas , José Elizandro Batista de Oliveira , Jose Isaque Do Nascimento Mangueira , Kailane Lourenço Araújo , Kaline de Araújo Medeiros , Luís Felipe Alves Dionísio , Wesley Natanael da Silva Lacerda

Drug Design and Discovery, Synthesis and Natural Products Phytopharmaceuticals. Isoprenoids. Antihelmintics

Insecticidal and repellent activity of Lippia gracilis essential oil on Aedes aegypti (Diptera: Culicidae)

Fabíola da Cruz Nunes , Jheison Marcos Claudino Franelino , Renan Tavares Leite

Drug Design and Discovery, Synthesis and Natural Products saw rosemary arboviruses carvacrol thymol biothecnology.

Insecticidal activity of Lippia gracilis essential oil on Aedes albopictus (Diptera: Culicidae)

Fabíola da Cruz Nunes , Jheison Marcos Claudino Francelino , Renan Tavares Leite , Thalita Barbosa Andrade

Drug Design and Discovery, Synthesis and Natural Products saw rosemary arboviruses carvacrol biotechnology.

SYNTHESIS AND EVALUATION OF THE ANTIMICROBIAL ACTIVITY OF A NEW PIPERINE DERIVATIVE

Bráulio de Almeida Teixeira , Edeltrudes de oliveira Lima , Francinara da Silva Alves , Gabriela Fehn Fiss , Helivaldo Diogenes da Silva Souza , ISABELA LIRA ANESIO , Michelle Valeriano de Lima , Petrônio Filgueiras Athayde-Filho

Drug Design and Discovery, Synthesis and Natural Products Piperine. Synthesis. Antimicrobial action.

Design, synthesis and antiviral evaluation of new peptidomimetics for chikungunya virus.

Edeildo Ferreira da Silva Junior , Ênio José Bassi , Érica Erlanny da Silva Rodrigues , Grazielle Lobo Coelho , João Xavier de Araújo-Júnior , Manuele Figueiredo da Silva , Stephannie Janaina Maia de Souza

Drug Design and Discovery, Synthesis and Natural Products Peptidomimetics; Antiviral; Arboviruses; CHIKV.

TRIAZOLE AS A PRIVILEGED STRUCTURE IN THE DISCOVERY OF NEW ANTIFUNGAL DRUGS

Alejandra Marigia Fragoso dos Santos , Allan moraes Silva , Beatriz Silva de Arruda Cardoso , Camile Rodrigues de Siqueira , Nathalya Patricia dos Santos Soares , Robert da Silva Tiburcio

Drug Design and Discovery, Synthesis and Natural Products Triazole Drugs Diseases Planning.

ISATIN AS A PRIVILEGED STRUCTURE IN THE DISCOVERY OF NEW ANTINEOPLASTIC MEDICINES

Alejandra Marigia Fragoso dos Santos , Allan Moraes Silva , Beatriz Silva de Arruda Cardoso , Nathalya Patricia dos Santos soares , Robert da Silva Tiburcio

Drug Design and Discovery, Synthesis and Natural Products Isatin Emerging Diseases Planning Cancer.

Developing Inhibitors Targenting Enhanced Intracellular Survival (Eis) Protein of Mycobacterium tuberculosis (Mtb)

Edeildo Ferreira da Silva Júnior , Francisco Jaime Bezerra Mendonça-Júnior , Igor José dos Santos Nascimento , Maria Eugênia Gouveia de Freitas , Midiane Correia Gomes , Thiago Mendonça de Aquino , Valnês S. Rodrigues Junior , Vitoria de Melo Batista

Drug Design and Discovery, Synthesis and Natural Products Quinazolinimines Thienopyrimidine Indole Mycobacterium tuberculosis Eis MTb.

IN VITRO AND IN SILICO DETERMINATION OF THE ANTILEISHMANIAL POTENTIAL OF SPIRO-ACRIDINE DERIVATIVES

Gleyton Leonel Silva Sousa , Igor José dos Santos Nascimento , Joilly Nilce Santana Gomes , Malu Maria Lucas dos Reis , Michelangela Suelleny de Caldas Nobre , Misael de Azevedo Teotônio Cavalcanti , Ricardo Olímpio de Moura , Sonaly Lima Albino

Drug Design and Discovery, Synthesis and Natural Products Spiro-acridines Leishmaniasis Molecular Docking In Vitro Studies CYP51 Topoisomerase I

Molecular docking and prediction model in the analysis of larvicidal activity of heterocyclic chalcone in Aedes aegypti (Diptera: Culicidae)

Fabíola da Cruz Nunes , Fernando Ferreira Leite , Francisco Jaime B. Mendonça , João Paulo Carvalho de Lima , Luís Fellipe Alves da Silva , Marcus Tullius Scotti , Maria Denise Leite Ferreira , Natália Ferreira de Sousa

Drug Design and Discovery, Synthesis and Natural Products Culicidae Synthetic insecticide Flavonoids

Development of New Benzothiazole Derivatives as Potential OFF-ON Fluorescent Probes for Quantification of Duplex DNA

Edeildo Ferreira da Silva-Júnio , Esaú Marques Brandão , Josué Carinhanha Caldas Santos , Kadja Luana Chagas Monteiro , Thiago Mendonça de Aquino

Drug Design and Discovery, Synthesis and Natural Products Fluorescent Probe; Benzothiazole; DNA Quantification.

PHYTOCHEMICAL SCREENING AND DETERMINATION OF THE MINIMUM INHIBITORY CONCENTRATION OF ETHANOLIC EXTRACT FROM CAPSICUM FRUTESCENS SEEDS AGAINST MULTI-RESISTANT STRAINS OF STAPHYLOCOCCUS AUREUS

ADEILSON ISRAEL VASCONCELOS CANDIDO , JANETE CLAIR DA SILVA SANTOS , MAXIMILIANA VITÓRIA DA SILVA OLIVEIRA , ORNELIANE MYRELY BEZERRA NOGUEIRA , PEDRO HENRIQUE DE SÁ LEAL , RAUL SOUSA ANDREZA , RHAYSSA LINDSAY AYRES DE LIMA CABRAL RAMOS

Drug Design and Discovery, Synthesis and Natural Products PHYTOCHEMICAL SCREENING;NATURAL PRODUCTS;STHAPHYLOCOCCUS AUREUS

DESIGN, SYNTHESIS AND EVALUATION OF NEW THIAZOLES AS PROMISING ANTI- SPOROTHRIX AGENTS

Ana Cristina Lima Leite , Lucas Manoel da Silva Sousa , Policarpo Ademar Sales Júnior , Reginaldo Gonçalves de Lima Neto , Robert da Silva Tibúrcio , Valéria Pereira Hernandes , Vanessa Gouveia de Melo Silva

Drug Design and Discovery, Synthesis and Natural Products Thiazole Derivatives Anti-Sporothrix Compounds Drug Design

Fragment-based drug design (FDD) of new prototypes based on the thienopyrimidine heterocycle to evaluate cytotoxicity and leishmanicidal effect.

Edeildo Ferreira da Silva Júnior , Igor José dos Santos Nascimento , João Kaycke Sarmento da Silva , João Xavier de Araújo Júnior , Magna Suzana Alexandre Moreira , Paulo Fernando da Silva Santos Júnior , Vitória de Melo Batista

Drug Design and Discovery, Synthesis and Natural Products Synthesis. Neglected disease. Drugs. Leishmaniasis.

Rational Development of New Acetylcholinesterase Inhibitors as Potential Drugs for Alzheimer's Disease

Edeildo Ferreira da Silva Junior , Kadja Luana Chagas Monteiro , Marcone Gomes dos Santos Alcantara , Nathalia Monteiro Lins Freire , Thiago Mendonça de Aquino , Vanessa Lima do Nascimento

Drug Design and Discovery, Synthesis and Natural Products Alzheimer's Disease Pharmacophoric modeling LBDD SBDD

PHYTOCHEMICAL SREENING AND IN VIVO WOUND HEALING ACTIVITY OF Micononia minutiflora (Bonpl.) DC. (MELASTOMATACEAE)

Abner Lins Dantas , Aline Stamford Henrique da Silva Guerra Gatis Carrazzoni , Elizabeth Fernanda de Oliveira Borba , José Rivaldo de Lima , Maria Luísa Novaes Cahú , Stella de Jesus Lourenço da Silva , Teresinha Gonçalves da Silva , Tonny Cley Campos Leite

Drug Design and Discovery, Synthesis and Natural Products methanolic extract medicinal plants wounds.

EVALUATION OF THE ANTIOXIDANT AND HEALING ACTIVITIES OF LEAF EXTRACTS OF Sideroxylon obtusifolium (ROEM. & SCHULT.) T. D. PENN.

Elayne Rayane Diniz Melo , Elizabeth Fernanda de Oliveira Borba1 , Mariana Monteiro do Nascimento , Michelly Rodrigues Pereira da Silva , Pedro Victor Rodrigues da Silva1 , Teresinha Gonçalves da Silva

Drug Design and Discovery, Synthesis and Natural Products Medicinal plants; Oxidative stress; Healin.

Lyophilization and characterization of Poly (lactic acid) (PLA) nanoparticles containing anti-leishmania drug candidates

Aléxia Gonçalves Dias , Camila de Oliveira Melo , Élquio Eleamen Oliveira , Francisco Jaime Bezerra Mendonça Junior , Izabele de Souza Araújo

Drug Design and Discovery, Synthesis and Natural Products thiophenic derivatives polymeric nanoparticles lyophilization

Development and in vitro investigation of the anti-leishmanial drug candidate SB-83 in polymeric nanoparticles

Aléxia Gonçalves Dias , Camila de Oliveira Melo , Élquio Eleamen Oliveira , Francisco Jaime Bezerra Mendonça Junior , Izabele de Souza Araújo , Klinger Antonio da Franca Rodrigues

Drug Design and Discovery, Synthesis and Natural Products Leishmaniasis. Thiophenic-amino-derivative. Polymeric nanoparticles.

Strategic 4-substituted 7-chloroquinolines: the search for antimicrobial agents against Escherichia coli, a neglected tropical disease

Everton da P. Silva , Gabriela F. Fiss , Helivaldo D. da S. Souza , Krystyna G. Lira , Maria F. da S. Madruga , Maria H. do Nascimento , Petrônio F. de Athayde-Filho , Rádamis B. Castor

Drug Design and Discovery, Synthesis and Natural Products Quinoline Lipophilicity Antimicrobial Activity.

DRUG DESIGN, SYNTHESIS AND IN VITRO ANTI-LEISHMANIA EVALUATION OF NEW DRUG CANDIDATES BASED ON 2-AMINOTHIOPHENE PROTOTYPES

Francisco Jaime Bezerra Mendonça Junior , Klinger Antônio da Franca Rodrigues , Natália Barbosa de Mélo , Vitória Gaspar Bernardo

Drug Design and Discovery, Synthesis and Natural Products drug design 2-aminothiophenes Gewald reaction

EVALUATION OF ANTIOXIDANT ACTIVITY AND QUANTIFICATION OF TOTAL PHENOLS IN THE ETHANOLIC EXTRACT OF GARCINIA BRASILIENSIS LEAVES

Alexandro Rodrigues Dantas , Fabíola Fernandes Galvão Rodrigues , Geane Gabriele de Oliveira Souza , Johnatan Wellisson da Silva Mendes , José Galberto Martins da Costa , José Walber Gonçalves Castro , Lariza Leisla Leandro Nascimento , Mariana Pereira da Silva

Drug Design and Discovery, Synthesis and Natural Products Antioxidant Natural products Garcinia brasiliensis

In vitro EVALUATION OF ANTI-Leishmania infantum ACTIVITY AND CYTOTOXIC PROFILE OF HOMODIMERIC 3-HYDROXYINDOLIN-2-ONE MORITA-BAYLIS-HILLMAN ADDUCTS

Ana Letícia Monteiro Fernandes , Cláudio Gabriel Lima-Junior , Fernanda Silva Almeida , Fernando Cézar Comberlang , Leonardo Lima Cardoso , Maísa Cavalcanti Coelho , Shayenne Eduarda Ramos Vanderley , Tatjana Souza Lima Keesen

Drug Design and Discovery, Synthesis and Natural Products Leishmanicidal activity; Morita-Baylis-Hillman; Topoisomerase

IN SILICO RATIONAL DESIGN AND CYTOTOXIC ACTIVITY OF AN ANTICANCER CANDIDATE DERIVED FROM D-GLUCOSE

Abner Lins Dantas , Elizabeth Fernanda de Oliveira Borba , George Torres de Lima , Juliano Carlo Rufino de Freitas , Rodrigo Ribeiro Alves Caiana , Tamires Figueirêdo Rodrigues Ribeiro Caiana , Teresinha Gonçalves da Silva , Yasmim Meneses Silva

Drug Design and Discovery, Synthesis and Natural Products Computer-aided drug design; Drugability; Carbohydrate; Leukemia

ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF THE HYDROALCOHOLIC EXTRACT OF THE LEAVES OF Terminalia catappa L. (COMBRETACEAE)

Abner Lins Dantas , Alexandra Débora Leite Borba , Beatriz de Fátima Maia de Santana , Elizabeth Fernanda de Oliveira Borba , Natacha Ferreira Albino Paixão , Pedro Victor Rodrigues da Silva , Teresinha Gonçalves da Silva , Yasmim Meneses Silva

Drug Design and Discovery, Synthesis and Natural Products Extract; Phytochemistry; Activity.

QUANTIFICATION OF TOTAL PHENOLS AND ANTIBACTERIAL ACTIVITY OF ETHANOLIC EXTRACT FROM THE SHELDS OF Ziziphus joazeiro Mart.

Alexandro Rodrigues Dantas , Joice Barbosa do Nascimento , José Galberto Martins da Costa1 , José Jonas Ferreira Viturino , José Walber Gonçalves Castro , Maria Inácio da Silva , Mariana Pereira da Silva , Natália Kelly Gomes de Carvalho

Drug Design and Discovery, Synthesis and Natural Products Ziziphus joazeiro antibacterial activity total phenols.

EVALUATION OF THE ANTIOXIDANT ACTIVITY AND CHEMICAL PROFILE OF DYSIDEA ETHERIA AND DESMAPSAMMA ANCHORATA EXTRACTS

Alexandro Rodrigues Dantas , Ana Cecília Calixto Donelardy , Carla de Fatima Alves Nonato , Cicera Janaine Camilo , Geane Gabriele de Oliveira Souza , Johnatan Wellisson da Silva Mendes , José Galberto Martins da Costa , José Walber Gonçalves Castro

Drug Design and Discovery, Synthesis and Natural Products Antioxidant Marine sponges DPPH.

EVALUATION OF ANTIOXIDANT ACTIVITY AND QUANTIFICATION OF TOTAL PHENOLS IN ETHYL ACETATE EXTRACT FROM THE PEELS OF Cnidoscolus quercifolius Pohl

Ana Cecília Calixto Donelardy , Carla de Fatima Alves Nonato , Geane Gabriele de Oliveira Souza , Johnatan Wellisson da Silva Mendes , Joice Barbosa do Nascimento , José Galberto Martins da Costa , Lariza Leisla Leandro Nascimento , Natália Kelly Gomes de Carvalho

Drug Design and Discovery, Synthesis and Natural Products Antioxidant Natural products Cnidoscolus quercifolius

Synthesis and In Silico Evaluation of New 2-Amino-Thiophene Derivatives and Their Isosteres as Promising Anti-Leishmania Agents

Bruna Kalyne Araújo da Silva , Francisco Jaime Bezerra Mendonça Junior , Marcus Tullius Scotti , Ricardo Eduardo Pereira Coutinho , Rodrigo Santos Aquino de Araújo

Drug Design and Discovery, Synthesis and Natural Products 2-Amino-thiophene Bioisosterism Medicinal Chemistry In Silico Evaluation

Discovery of 1,2,4-oxadiazole derivatives as inhibitors towards 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti

Andrew A. Oliveira , Janaína V. dos Anjos , Larissa G. Maciel , Laylla L. L. Leal , Maria Helena N. L. Silva-Filha , Rafael V. C. Guido , Tatiany P. Romão , Thereza A. Soares

Drug Design and Discovery, Synthesis and Natural Products Larvicidal agents xanthurenic acid detection new recombinant HKT

CHEMICAL PROFILE AND ANTIBACTERIAL ACTIVITY OF METHANOLIC EXTRACT FROM THE STEM BARK OF Cnidoscolus quercifolius Pohl.

Ana Cecília Calixto Donelardy , Fabiola Fernandes Galvão Rodrigues , Joice Barbosa do Nascimento , José Galberto Martins da Costa , José Jonas Ferreira Viturino , José Walber Gonçalves Castro , Maria Inácio da Silva , Mariana Pereira da Silva

Drug Design and Discovery, Synthesis and Natural Products Cnidoscolus quercifolius antibacterial activity chemical composition.

Drug Design and Synthesis of New 2-Amino Selenophenes Anti-leishmanial Drugs Candidates

Francisco Jaime Bezerra Mendonça Junior , Ricardo Eduardo Pereira Coutinho , Rodrigo Santos Aquino de Araújo

Drug Design and Discovery, Synthesis and Natural Products 2-Amino-selenophenes; Medicinal Chemistry; Leishmaniasis; Bioisosterism.

Activity of 2-aminothiophene compounds against Escherichia coli

Cícera Datiane de Morais Oliveira-Tintino , Francisco Jaime Bezerra Mendonça Junior , Gustavo Miguel Siqueira , Henrique Douglas Melo Coutinho , João Arthur de Oliveira Borges , Priscilla Augusta de Sousa Fernandes

Drug Design and Discovery, Synthesis and Natural Products Synergism; 2-aminothiophenes; Antimicrobial activity;

In silico and antiparasitic activity against Giardia lamblia of Morita–Baylis–Hillman adducts derived from Thymol

Abrahão Alves de Oliveira Filho , Aleff Cruz de Castro , Andressa Brito Lira , Claudio Gabriel Lima?Junior , Elaine Maria de Souza Fagundes , Francisco José Seixas Xavier , Hermita Érika de Sousa , Maria Aparecida Gomes

Drug Design and Discovery, Synthesis and Natural Products Giardicidal activity; Cytotoxicity; MBH reaction.

CHEMICAL PROFILE AND ANTIOXIDANT ACTIVITY OF ETHYL ACETATE EXTRACT FROM LEAVES AND SEEDS OF Anadenanthera Colubrina (Vell.) Brenan

Ana Cecília Calixto Donelardy , Geane Gabriele de Oliveira Souza , Joice Barbosa do Nascimento , José Galberto Martins da Costa , José Jonas Ferreira Viturino , José Walber Gonçalves Castro , MARIA INÁCIO DA SILVA , Mariana Pereira da Silva

Drug Design and Discovery, Synthesis and Natural Products Anadenanthera colubrina chemical prospecting antioxidant activity.

CHEMICAL COMPOSITION AND EVALUATION OF THE ANTIMICROBIAL AND MODULATORY ACTIVITY OF ESSENTIAL OIL FROM Croton grewioides BAILL

Cícera Janaine Camilo , Geane Gabriele de Oliveira Souza , Joice Barbosa do Nascimento , José Galberto Martins da Costa , José Jonas Ferreira Viturino , José Walber Gonçalves de Castro , Maria Inacio da Silva , Mariana Pereira da Silva

Drug Design and Discovery, Synthesis and Natural Products Chemical composition; Modulation; Essential oil; Synergism;

REPOSITIONING DRUGS IN THE TREATMENT OF SCHISTOSOMIASIS: WHAT'S PROMISING?

Ana Vithoria da Silva Melo , Bruna Cristiane Souza França , Demis Ferreira de Melo , Larissa Araújo Rolim , Laysa Creusa Paes Barreto Barros Silva , Natália Millena da Silva , Pedro José Rolim Neto

Drug Design and Discovery, Synthesis and Natural Products Schistosomiasis Drug repurposing Drug repositioning Treatment

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF COMPOUNDS DERIVED FROM 2-STYRYLQUINOLINE-4-CARBOXYLIC ACID

Ashley Andersson Santos Santana de Jesus , Claudio Gabriel Lima?Junior , Edeltrudes de Oliveira Lima , José Roberto Dantas , Lidiane Gomes de Araújo , Rodrigo Cristiano

Drug Design and Discovery, Synthesis and Natural Products Styrylquinolines Pfitzinger reaction Knoevenagel reaction antibacterial activity antifungal activity.

ANALYSIS OF in vitro ANTI-LEISHMANIAL ACTIVITY OF ISATINS IN Leishmania infantum

Ana Leticia Monteiro Fernandes , Delva Thyares Fonseca Lamec , Fernanda Silva Almeida , Juliana Alves Vale , Leonardo Lima Cardoso , Paloma Gomes de Abrantes , Shayenne Eduarda Ramos Vanderley , Tatjana Souza Lima Keesen

Drug Design and Discovery, Synthesis and Natural Products visceral leishmaniasis; synthetic compounds; biological activity

Phytochemical composition, cytotoxicity and acute toxicity of the ethyl acetate extract from Clidemia hirta leaves

Abner Lins Dantas , Elizabeth Fernanda de Oliveira Borba , Marília Grasielly de Farias Silva , Marley Gabriel da Silva Santos , Nara de Melo Santos , STELLA DE JESUS LOURENCO DA SILVA , Teresinha Gonçalves da Silva , Tonny Cley Campos Leite

Drug Design and Discovery, Synthesis and Natural Products Cancer Phytochemistry Medicinal plants Toxicology

Design of 2-thiopyrimidinones derivatives as new aldose reductase inhibitors via alkyne-azide click reaction

Ilaria Martina Silva Lins , Janaína Versiani dos Anjos , Larissa Gonçalves Maciel

Drug Design and Discovery, Synthesis and Natural Products aldose reductase CuAAC thyopirimidinones inhibition molecular docking

New Insights into the anticancer effects of two ?-lapachone derivatives on solid tumors cells

Abner Lins Dantas , Alexandre José da Silva Góes , Elayne Rayane Diniz Melo , Elizabeth Fernanda de Oliveira Borba , George Torres de Lima , José Rivaldo de Lima , Mariza Severina de Lima Silva , Teresinha Gonçalves da Silva

Drug Design and Discovery, Synthesis and Natural Products Naphthoquinone Apoptosis Necrosis.

EVALUATION OF THE ANTICANCER POTENTIAL OF ARYL SEMICARBAZONE AND ARYL THIOSEMICARBAZONE DERIVATES

ABNER LINS DANTAS , George Torres Lima , José Dalci Brondani , José Rivaldo de Lima , Rodrigo Ribeiro Alves Caiana , Stella de Jesus Lourenço da Silva , Teresinha Gonçalves da Silva1 , Yasmim Meneses Silva

Drug Design and Discovery, Synthesis and Natural Products Anticancer cytotoxicity semicarbazones and thiosemicarbazones

Oxadiazolinones as potential ACE inhibitors

Janaína Versiani dos Anjos , Larissa Fernanda Lima Ferreira , Larissa Gonçalves Maciel , Sidney Gustavo Diniz Feitosa

Drug Design and Discovery, Synthesis and Natural Products oxadiazolidin-5-ones; molecular docking; selective inhibitors

PHYTOCHEMICAL PROFILE AND IN VITRO ANTIBACTERIAL ACTIVITY OF EXTRACT OBTAINED FROM THE REUSE OF LEAF BIOMASS OF Citrus limon

Everton Vieira da Silva , Jonathas David de Brito , Manoel Alencar Souto Neto , Sávio Benvindo Ferreira , Whellinton Flávio Batista Duarte

Drug Design and Discovery, Synthesis and Natural Products Bioactivity; Natural products; Phytochemistry.

Voltar

Biology, Pharmacology and Physiology
Drug Design and Discovery, Synthesis and Natural Products
Quimioinformatics, Bioinformatics and TheoreticalChemistry